p53 Arg72Pro and MDM2 309 SNPs in hereditary retinoblastoma
نویسندگان
چکیده
منابع مشابه
Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma.
Epidemiological studies of the association of variants p53 Arg72Pro and MDM2 single-nucleotide polymorphism 309 (SNP309) with glioma risk have produced inconsistent results. The aim of the current study was to evaluate the association of these 2 variants with glioma susceptibility using a meta-analysis approach. For p53 Arg72Pro, 10 case-control studies including 2587 glioma patients and 40...
متن کاملClinical relevance of MDM2 SNP 309 and TP53 Arg72Pro in follicular lymphoma.
David Wrench, Rachel Waters, Emanuela Carlotti, Sameena Iqbal, Janet Matthews, Marie Calaminici, John Gribben, T Andrew Lister, Jude Fitzgibbon Centre for Medical Oncology, Barts and the London School of Medicine, London, UK; Centre for Statistics in Medicine, University of Oxford, Oxford, UK; Data Management Unit, Medical Oncology Department, Barts and the London NHS Trust, London, UK; Histopa...
متن کاملMDM2 SNP309 (rs2279744) and p53 Codon Arg72Pro (rs1042522) SNP in Cervical Carcinogenesis
To investigate the association between polymorphisms (SNP) in the p53 and murine double minute 2 homolog (MDM2) promoter 309 in cervical carcinogenesis. SNP at p53 codon 72 polymorphisms and MDM2 promoter 309 (T/G) together with human papillomavirus (HPV) types were examined in a total of 187 cervical smear samples using real time PCR. 27 cases with HPV types 16 and/or 18 had significantly high...
متن کاملThe significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast cancer.
The p53 protein and its regulator MDM2 is central to tumorigenesis by directing cells to undergo cell cycle arrest and/or apoptosis in response to DNA damage or other stress signals. The genes encoding these proteins contain nucleotide variation (p53 codon 72, MDM2 SNP309) that influences cellular response. We examined the p53 codon 72 and MDM2 SNP309 to determine their implication with age of ...
متن کاملp53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis.
PURPOSE This study aimed to evaluate the prognostic significance of two functional single nucleotide polymorphisms (SNP) in the p53 pathway (p53 Arg72Pro and MDM2 T309G) in patients with esophageal cancer, and to determine the importance of histologic subtype in the SNP-outcome relationships. EXPERIMENTAL DESIGN A cohort of 371 patients with esophageal carcinoma enrolled in Boston, USA from 1...
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ژورنال
عنوان ژورنال: Journal of Human Genetics
سال: 2011
ISSN: 1434-5161,1435-232X
DOI: 10.1038/jhg.2011.82